You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088 (1-800-332-1088).

If you cannot afford your medication, contact for assistance.

Surgical Options

If you are considering surgery or other procedures, you may be interested to know that there are many options, depending on your individual situation. The procedure your doctor may recommend depends on the number of fibroids you have, where they are located and your health.

Photo of woman

Models are for illustrative purposes only.

Making the right decision for you

There is a lot to think about when deciding how to treat uterine fibroids. You and your doctor should consider your specific situation before taking the next step. The more knowledge and information you have, the more you can be a part of managing your condition. Talk with your doctor to learn more about your options, and to get the details of the surgery he or she recommends.

Pre-surgical preparation

Lupron Depot is used with iron therapy before fibroid surgery to improve anemia related to fibroids.

The most common side effects of Lupron Depot include hot flashes, vaginal dryness, headaches, changes in mood, decreased interest in sex, depression, and/or the occurrence of forgetfulness.

Please see Important Safety Information you should know about Lupron Depot and discuss it with your doctor.

Please see the full Prescribing Information for Lupron Depot.

Surgical options

Lupron Depot has been studied in clinical trials where hysterectomy and myomectomy were performed.


Hysterectomy might be an option for a woman who is near the end of her reproductive years, or isn’t concerned about fertility. It might also be considered if the fibroids are causing serious complications or especially uncomfortable symptoms. It is important to understand that a hysterectomy permanently removes your uterus. A woman cannot become pregnant after having a hysterectomy. Sometimes the ovaries and fallopian tubes are also removed during the procedure. If the ovaries are removed during the procedure, hysterectomy causes immediate menopause.


Myomectomy involves the surgical removal of uterine fibroids without the removal of the uterus. Therefore, myomectomy may be a good choice for women who want to keep the option of becoming pregnant and having children.

Myomectomy is often successful in reducing menstrual flow caused by fibroids.4 However, it is important to realize that, with myomectomy, fibroids may return and need further treatment.

There are other procedures or surgical options for uterine fibroids. The following have not been studied in clinical trials with Lupron Depot: myolysis,5 MRI-guided ultrasound and uterine fibroid embolization (UFE),6 also known as uterine artery embolization (UAE).

If you have any questions about this information, talk to your doctor.

Use and Important Safety Information You Should Know About Lupron Depot® (leuprolide acetate for depot suspension)


LUPRON DEPOT® (leuprolide acetate for depot suspension) 3.75 mg for 1-month and 11.25 mg for 3-month administration with iron therapy are used before fibroid surgery to improve anemia due to vaginal bleeding from fibroids. Your doctor may consider a one-month trial of iron alone as some patients’ anemia will improve with iron alone. It is recommended that LUPRON DEPOT not be used for more than 3 months in patients with fibroids. Experience with LUPRON DEPOT in females has been limited to women 18 years of age and older.

Important Safety Information

Do not take LUPRON DEPOT if you are or may become pregnant, are breast-feeding, have undiagnosed vaginal bleeding, or if you have experienced any type of allergic reaction to LUPRON DEPOT or similar drugs.

Thinning of the bones may occur during therapy with LUPRON DEPOT, which may not be completely reversible in some patients. Since some conditions may increase the possibility of bone thinning, you should tell your doctor if you smoke, use alcohol in excess, have a family history of osteoporosis (thinning of the bones with fractures), or are taking other medications that can cause thinning of the bones.

After beginning LUPRON DEPOT, your estrogen levels will increase for 1 or 2 weeks. During this time, you may notice an increase in your current symptoms. You should notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.

LUPRON DEPOT is not a method of birth control. Even though you may not have periods, unprotected intercourse could result in pregnancy. You should use non-hormonal birth control such as condoms, a diaphragm with contraceptive jelly, or a copper IUD to prevent pregnancy. If you think you have become pregnant while on LUPRON DEPOT, talk to your doctor immediately.

There is a possibility of the development or worsening of depression and/or the occurrence of forgetfulness. Patients who have a history of depression should be carefully observed during treatment.

Convulsions have been observed in patients taking leuprolide acetate.

The most common side effects of LUPRON DEPOT include hot flashes, vaginal dryness, headaches, changes in mood, decreased interest in sex, depression, and/or the occurrence of forgetfulness.

LUPRON DEPOT must be administered in your doctor’s office.

For more information, talk with your health care provider.