Is Lupron Depot Right for You?

Lupron Depot is used with iron therapy before fibroid surgery to improve anemia related to fibroids. If your doctor has prescribed Lupron Depot, they believe it may help you prepare for fibroid surgery. There are a few reasons why a woman should not start or continue Lupron Depot therapy. It should not be taken if you are:

  • Pregnant
  • Breast-feeding
  • Experiencing undiagnosed, abnormal vaginal bleeding
  • Allergic to any of the ingredients in Lupron Depot

Please see Important Safety Information you should know about Lupron Depot and discuss it with your doctor.

Please see the full Prescribing Information for Lupron Depot.

What to expect during Lupron Depot therapy

Lupron Depot works by decreasing the amount of estrogen that your ovaries produce. Estrogen produced in the ovaries affects a woman’s menstrual cycle. When menstruation starts, fibroids may also bleed, which, if excessive, can lead to anemia.

After beginning Lupron Depot, your estrogen levels will increase for 1 or 2 weeks. During this time, you may notice an increase in your current symptoms. You should notify your doctor if you develop any new or worsened symptoms after beginning Lupron Depot treatment.

During Lupron Depot therapy you may experience symptoms such as hot flashes, headaches, and vaginal dryness, as a result of lower estrogen levels. These side effects should disappear and your estrogen level should gradually return to normal after you have finished your course of treatment with Lupron Depot.

Some other common side effects of Lupron Depot include changes in mood, decreased interest in sex, depression, and/or the occurrence of forgetfulness.

In a study of uterine fibroid patients, a bone mineral density loss of 2.7% at month 3 occurred during therapy.7

It’s important to let your doctor know about any symptoms that you have during your treatment with Lupron Depot. This will help your doctor better monitor your progress.

Other side effects

Some women may have a light period or spotting during Lupron Depot therapy, but most will stop menstruating after the second month of treatment. Periods usually return two months after the treatment stops. If you don’t get your period within three months after stopping Lupron Depot therapy, talk to your doctor.

There is also a possibility of the development or worsening of depression and/or the occurrence of forgetfulness. Convulsions have also been observed in patients taking leuprolide acetate.

Pregnancy while on Lupron Depot

You should not use Lupron Depot if you are or may become pregnant. Lupron Depot is not a method of birth control. Even though you may not have periods, unprotected intercourse could result in pregnancy. If you are sexually active, it is important that you use a nonhormonal contraceptive (such as condoms, a diaphragm with contraceptive jelly, or a copper IUD) as a preventative measure. If you think you are pregnant during your Lupron Depot therapy, tell your doctor immediately.

Use and Important Safety Information You Should Know About Lupron Depot® (leuprolide acetate for depot suspension)

Use

LUPRON DEPOT® (leuprolide acetate for depot suspension) 3.75 mg for 1-month and 11.25 mg for 3-month administration with iron therapy are used before fibroid surgery to improve anemia due to vaginal bleeding from fibroids. Your doctor may consider a one-month trial of iron alone as some patients’ anemia will improve with iron alone. It is recommended that LUPRON DEPOT not be used for more than 3 months in patients with fibroids. Experience with LUPRON DEPOT in females has been limited to women 18 years of age and older.

Important Safety Information

Do not take LUPRON DEPOT if you are or may become pregnant, are breast-feeding, have undiagnosed vaginal bleeding, or if you have experienced any type of allergic reaction to LUPRON DEPOT or similar drugs.

Thinning of the bones may occur during therapy with LUPRON DEPOT, which may not be completely reversible in some patients. Since some conditions may increase the possibility of bone thinning, you should tell your doctor if you smoke, use alcohol in excess, have a family history of osteoporosis (thinning of the bones with fractures), or are taking other medications that can cause thinning of the bones.

After beginning LUPRON DEPOT, your estrogen levels will increase for 1 or 2 weeks. During this time, you may notice an increase in your current symptoms. You should notify your doctor if you develop any new or worsened symptoms after beginning LUPRON DEPOT treatment.

LUPRON DEPOT is not a method of birth control. Even though you may not have periods, unprotected intercourse could result in pregnancy. You should use non-hormonal birth control such as condoms, a diaphragm with contraceptive jelly, or a copper IUD to prevent pregnancy. If you think you have become pregnant while on LUPRON DEPOT, talk to your doctor immediately.

There is a possibility of the development or worsening of depression and/or the occurrence of forgetfulness. Patients who have a history of depression should be carefully observed during treatment.

Convulsions have been observed in patients taking leuprolide acetate.

The most common side effects of LUPRON DEPOT include hot flashes, vaginal dryness, headaches, changes in mood, decreased interest in sex, depression, and/or the occurrence of forgetfulness.

LUPRON DEPOT must be administered in your doctor’s office.

For more information, talk with your health care provider.

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